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Advantage® II combines the properties of the original formulations of Advantage Topical Solution, with the insect growth regulator (IGR) pyriproxyfen, which inhibits the development of flea eggs and kills flea larvae.

Advantage II starts killing fleas in an hour. Within 12 hours of initial application, 98-100 percent of all existing fleas on pets are dead. Advantage® II is for puppies seven weeks of age and older.