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Revolution for dogs 40.1 to 85 lbs (6 Month)

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REVOLUTION (selamectin) is the veterinarian’s #1 choice for a safe, effective way to protect cats from fleas, heartworms and other harmful parasites. Revolution is a topical liquid medication, effective in preventing heartworm disease, killing fleas, treating and controlling ear mites and sarcoptic mites and controlling American dog tick infestations. Applied once a month at one spot on the skin (typically between the shoulders). It can be used for dogs and cats 6 weeks or older.

Revolution is recommended for use in dogs six weeks of age or older and cats eight weeks of age and older for the following parasites and indications:

Dogs: Revolution kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the prevention and control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilaria immitis, and the treatment and control of ear mite (Otodectes cynotis) infestations. Revolution also is indicated for the treatment and control of sarcoptic mange (Sarcoptes scabiei) and for the control of tick infestations due to Dermacentor variabilis.

Cats: Revolution kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the prevention and control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilaria immitis, and the treatment and control of ear mite (Otodectes cynotis) infestations. Revolution is also indicated for the treatment and control of roundworm (Toxocara cati) and intestinal hookworm (Ancylostoma tubaeforme) infections in cats.

WARNINGS: Not for human use. Keep out of the reach of children. In humans, Revolution may be irritating to skin and eyes. Reactions such as hives, itching and skin redness have been reported in humans in rare instances. Individuals with known hypersensitivity to Revolution should use the product with caution or consult a health care professional. Revolution contains isopropyl alcohol and the preservative butylated hydroxytoluene (BHT). Wash hands after use and wash off any product in contact with the skin immediately with soap and water. If contact with eyes occurs, then flush eyes copiously with water. In case of ingestion by a human, contact a physician immediately.
For the prevention and control of flea infestations, Revolution should be administered at monthly intervals throughout the flea season, starting one month before fleas become active. In controlled laboratory studies >98% of fleas were killed within 36 hours. Results of clinical field studies using Revolution monthly demonstrated >90% control of flea infestations within 30 days of the first dose. Dogs and cats treated with Revolution, including those with pre-existing flea allergy dermatitis, showed improvement in clinical signs associated with fleas as a direct result of eliminating the fleas from the animals and their environment.

If the dog or cat is already infested with fleas when the first dose of Revolution is administered, adult fleas on the animal are killed and no viable fleas hatch from eggs after the first administration. However, an environmental infestation of fleas may persist for a short time after beginning treatment with Revolution because of the emergence of adult fleas from pupae.

DOSAGE: The recommended minimum dose is 2.7 mg selamectin per pound (6 mg/kg) of body weight. Administer the entire contents of a single dose tube (or two tubes used in combination for dogs weighing over 130 pounds) of Revolution topically in accordance with the following tables. (See ADMINISTRATION for the recommended treatment intervals.)

Cats (lb) Package color (mg/mL) mg per tube Potency Administered volume (mL)
Up to 5 Mauve 15 mg 60 .25
5.1–15 Blue 45 mg 60 .75
15.1–22 Taupe 60 mg 60 1.0


For cats over 22 lbs use the appropriate combination of tubes.

Dogs  (lb) Package color (mg/mL) mg per tube Potency Administered volume (mL)
Up to 5 Mauve 15 mg 60 .25
5.1–10      Purple 30 mg 120 .25
10.1–20 Brown 60 mg 120 .5
20.1–40 Red 120 mg 120 1
40.1–85 Teal 240 mg 120 2
85.1–130 Plum 360 mg 120 3
The content of each tube is formulated to provide a minimum of 2.7 mg/lb (6 mg/kg) of body weight of selamectin. The chemical composition of selamectin is (5Z,25S)-25-cyclohexyl- 4’- O- de(2,6-dideoxy-3- O- methyl- α -L- arabino -hexopyranosyl)-5-demethoxy-25-de(1-methylpropyl)-22,23- dihydro-5-hydroxyimino avermectin A 1a .